Highlights in breast cancer from the 2014 American Society of Clinical Oncology® annual meeting.
نویسنده
چکیده
Women with high-risk HER2-negative breast cancer do not benefit from the addition of bevacizumab (Avastin, Genentech) to standard chemotherapy, according to results from the Eastern Cooperative Oncology Group 5103 (E5103) trial. “Our results are quite similar to those reported previously for the BEATRICE and the BETH trials, which enrolled patients with HER2-positive disease,” said presenter Dr Kathy Miller of the Indiana University School of Medicine in Indianapolis. (BEATRICE refers to the Adjuvant Bevacizumab-Containing Therapy in Triple-Negative Breast Cancer trial, and BETH refers to the Treatment of HER2 Positive Breast Cancer With Chemotherapy Plus Trastuzumab vs Chemotherapy Plus Trastuzumab Plus Bevacizumab trial). The E5103 study included 4994 patients with a median age of 52 years who had HER2-negative breast cancer that was considered high risk because of positive lymph nodes, negative estrogen receptor status in a tumor of at least 1 cm, or positive estrogen receptor status in a tumor of at least 5 cm or with an oncotype recurrence score of 11 or higher. All patients received doxorubicin and cyclophosphamide followed by weekly paclitaxel, and were randomly assigned to receive placebo, bevacizumab during chemotherapy, or bevacizumab during chemotherapy followed by bevacizumab monotherapy. After a median follow-up of 47.5 months, invasive disease–free survival was 77% in the placebo group, 76% in the bevacizumab during chemotherapy group, and 80% in the bevacizumab during chemotherapy followed by bevacizumab monotherapy group. The hazard reduction between the bevacizumab during chemotherapy followed by bevacizumab monotherapy group and the Genomic Analysis Predicts Response to Trastuzumab
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ورودعنوان ژورنال:
- Clinical advances in hematology & oncology : H&O
دوره 12 7 شماره
صفحات -
تاریخ انتشار 2014